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Yen-Nan Lin

Visiting Researcher, Chemistry

Bio

Yen-Nan Lin, MD, PhD is a Gastroenterology Fellow at the University of Pittsburgh Medical Center (UPMC) and a Visiting Researcher at Â鶹´å. A board-certified clinical internist, Dr. Lin completed his MD and PhD in Chemistry at Texas A&M University under the mentorship of Dr. Karen L. Wooley, focusing on controlling the physicochemical properties of nanomaterials toward personalized medicine.   Currently under mentorship of Professor Krzysztof Matyjaszewski at Â鶹´å, Dr. Lin’s research centers on molecularly engineered materials that can selectively modify the gastrointestinal microenvironment and host–microbe interactions. Currently working on engineering nonabsorbable, biguanide-functionalized therapeutic polymers designed for gastrointestinal-localized antimicrobial activity. By integrating advanced macromolecular chemistry with clinical gastroenterology, he aims to develop nonabsorbable biomaterials that treat enteric pathogens and targeted GI dysbiosis without systemic toxicity.

Education

Publications

1. Swetha Tummala, Andy Wu, Yen-Nan Lin, Tiarra Price, Anthony Demetris, Stela Celaj. Uncommon Case of Hemophagocytic Lymphohistiocytosis as the First Presentation of Systemic Lupus Erythematosus. ACG Case Reports Journal 13 (5), e02133
2. Lu Su, Kellie S Dalby, Hannah Luehmann, Sussana A Elkassih, Sangho Cho, Xun He, Lisa Detering, Yen-Nan Lin, Nari Kang, Dennis A Moore, Richard Laforest, Guorong Sun, Yongjian Liu, Karen L Wooley.  Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers. Acta Pharmaceutica Sinica B 2023, 13 (4): 1660-1670. doi: 10.1016/j.apsb.2022.09.009.
3. Yue Song, Mahmoud Elsabahy, Christina A Collins, Sarosh Khan, Richen Li, Teri N Hreha, Yidan Shen, Yen-Nan Lin, Rachel A Letteri, Lu Su, Mei Dong, Fuwu Zhang, David A Hunstad, Karen L Wooley. Morphologic design of silver-bearing sugar-based polymer nanoparticles for uroepithelial cell binding and antimicrobial delivery. Nano Letters 2021, 21 (12): 4990-4998. doi: 10.1021/acs.nanolett.1c00776.
4. Yen-Nan Lin, Sarosh Khan, Yue Song, Mei Dong, Yidan Shen, David K Tran, Ching Pang, Fuwu Zhang, Karen L Wooley. A tale of drug-carrier optimization: controlling stimuli sensitivity via nanoparticle hydrophobicity through drug loading. Nano Letters 2020, 20 (9): 6563-6571. doi: 10.1021/acs.nanolett.0c02319.
5. Yue Song, Xin Yang, Yidan Shen, Mei Dong, Yen-Nan Lin, Michael B Hall, Karen L Wooley. Invoking side-chain functionality for the mediation of regioselectivity during ring-opening polymerization of glucose carbonates. Journal of the American Chemical Society 2020, 142 (40): 16974-16981. doi: 10.1021/jacs.0c05610.
6. Yen-Nan Lin, Mahmoud Elsabahy, Sarosh Khan, Fuwu Zhang, Yue Song, Mei Dong, Richen Li, Justin Smolen, Rachel A. Letteri, Lu Su, Karen L. Wooley. Erythrocyte-membrane-camouflaged nanocarriers with tunable paclitaxel release kinetics via macromolecular stereocomplexation. ACS Materials Letters 2020, 2: 595-601. doi: 10.1021/acsmaterialslett.0c00044.
7. Mei Dong, Yue Song, Hai Wang, Lu Su, Yidan Shen, David K Tran, Rachel A Letteri, Jeniree A Flores, Yen-Nan Lin, Jialuo Li, Karen L Wooley. Degradable sugar-based magnetic hybrid nanoparticles for recovery of crude oil from aqueous environments. Polymer Chemistry 2020, 11 (30): 4895-4903. doi: 10.1039/D0PY00029A.
8. Mei Dong, Michiel G Wessels, Jee Young Lee, Lu Su, Hai Wang, Rachel A Letteri, Yue Song, Yen-Nan Lin, Yingchao Chen, Richen Li, Darrin J Pochan, Arthi Jayaraman, Karen L Wooley. Experiments and simulations of complex sugar-based coil-brush block polymer nanoassemblies in Aqueous Solution. ACS Nano 2019, 13 (5): 5147-5162. doi: 10.1021/acsnano.8b08811.
9. Richen Li, Hai Wang, Yue Song, Yen-Nan Lin, Mei Dong, Yidan Shen, Sarosh Khan, Shiyi Zhang, Jingwei Fan, Fuwu Zhang, Lu Su, Karen L Wooley. In situ production of Ag/polymer asymmetric nanoparticles via a powerful light-driven technique. Journal of the American Chemical Society 2019, 141 (50): 19542-19545. doi: 10.1021/jacs.9b10205.
10. Shota Osumi, Simcha E Felder, Hai Wang, Yen-Nan Lin, Mei Dong, Karen L Wooley. Construction of nanostructures in aqueous solution from amphiphilic glucose-derived polycarbonates. Journal of Polymer Science Part A: Polymer Chemistry 2019, 57 (3): 432-440. doi: 10.1002/pola.29229.
11. Yen-Nan Lin, Lu Su, Justin Smolen, Richen Li, Yue Song, Hai Wang, Mei Dong, Karen L Wooley. Co-assembly of sugar-based amphiphilic block polymers to achieve nanoparticles with tunable morphology, size, surface charge, and acid-responsive behavior. Materials Chemistry Frontiers 2018, 2 (12): 2230-2238. doi: 10.1039/C8QM00353J.
12. Yue Song, Xiaozhou Ji, Mei Dong, Richen Li, Yen-Nan Lin, Hai Wang, Karen L Wooley. Advancing the development of highly-functionalizable glucose-based polycarbonates by tuning of the glass transition temperature. Journal of the American Chemical Society 2018, 140 (47): 16053-16057. doi: 10.1021/jacs.8b10675.
13. Hai Wang, Mei Dong, Sarosh Khan, Lu Su, Richen Li, Yue Song, Yen-Nan Lin, Nari Kang, Christopher H Komatsu, Mahmoud Elsabahy, Karen L Wooley. Acid-triggered polymer backbone degradation and disassembly to achieve release of camptothecin from functional polyphosphoramidate nanoparticles. ACS Macro Letters 2018, 7 (7): 783–788. doi: 10.1021/acsmacrolett.8b00377.
14. Lu Su, Richen Li, Sarosh Khan, Ryan Clanton, Fuwu Zhang, Yen-Nan Lin, Yue Song, Hai Wang, Jingwei Fan, Soleil Hernandez, Andrew S Butters, Gamal Akabani, Ronan MacLoughlin, Justin Smolen, Karen L Wooley. Chemical design of both a glutathione-sensitive dimeric drug guest and a glucose-derived nanocarrier host to achieve enhanced osteosarcoma lung metastatic anticancer selectivity. Journal of the American Chemical Society 2018, 140 (4): 1438-1446. doi: 10.1021/jacs.7b11462.
15. Lu Su, Gyu Seong Heo, Yen‐Nan Lin, Mei Dong, Shiyi Zhang, Yingchao Chen, Guorong Sun, Karen L Wooley. Syntheses of triblock bottlebrush polymers through sequential ROMPs: Expanding the functionalities of molecular brushes. Journal of Polymer Science Part A: Polymer Chemistry 2017, 55 (18): 2966-2970. doi: 10.1002/pola.28647.
16. Lu Su, Sarosh Khan, Jingwei Fan, Yen-Nan Lin, Hai Wang, Tiffany P Gustafson, Fuwu Zhang, Karen L Wooley. Functional sugar-based polymers and nanostructures comprised of degradable poly (D-glucose carbonate)s. Royal Society of Chemistry 2017, 8 (10): 1699-1707. doi: 10.1039/C6PY01978A.